The mouse peer review system was commissioned in a small animal irradiator using anterior-posterior and posterior-anterior beams of 225 kVp and then mailed to three institutions to test the feasibility of the audit service. The phantom accommodates three thermoluminescent dosimeters (TLDs) to measure dose. A robust, user-friendly mouse phantom was constructed from high-impact polystyrene and designed with dimensions similar to those of a typical laboratory mouse. The purpose of this study was to develop a mail-based, independent peer review system to verify dose delivery among institutions using X-RAD 225Cx irradiators (Precision X-Ray, North Branford, CT). However, there is a lack of dosimetric standardization among these irradiators, which affects the reproducibility of radiation-based animal studies. Dedicated precision orthovoltage small animal irradiators have become widely available in the past decade and are commonly used for radiation biology research.
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